Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of tauopathy. Since misfolded tau has been shown to transmit across synapses in AD animal models...

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Huvudupphovsmän: Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209049/
https://ncbi.nlm.nih.gov/pubmed/25330988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0146-2
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