Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of tauopathy. Since misfolded tau has been shown to transmit across synapses in AD animal models...

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Hlavní autoři: Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209049/
https://ncbi.nlm.nih.gov/pubmed/25330988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0146-2
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