Embryo-transfer of the F2 Postnatal Calorie Restricted Female Rat Offspring into a Control Intra-uterine Environment Normalizes the Metabolic Phenotype

OBJECTIVE: Postnatal calorie and growth restriction (PNGR) in the first generation (F1) rat female offspring causes a lean and glucose tolerant phenotype associated with hypoinsulinemia and reduced glucose-stimulated insulin secretion (GSIS). Despite the absence of gestational hyperglycemia in the F...

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Autori principali: Garg, Meena, Thamotharan, Manikkavasagar, Dai, Yun, Lee, Paul W.N., Devaskar, Sherin U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208919/
https://ncbi.nlm.nih.gov/pubmed/23021963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2012.08.026
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