DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

The specific mechanisms how lung cancer cells harboring epidermal growth factor receptor (EGFR) activating mutations can survive treatment with EGFR-tyrosine kinase inhibitors (TKIs) until they eventually acquire treatment-resistance genetic mutations are unclear. The phenotypic diversity of cancer...

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Autores principales: Nozaki, Koichiro, Kagamu, Hiroshi, Shoji, Satoshi, Igarashi, Natsue, Ohtsubo, Aya, Okajima, Masaaki, Miura, Satoru, Watanabe, Satoshi, Yoshizawa, Hirohisa, Narita, Ichiei
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208809/
https://ncbi.nlm.nih.gov/pubmed/25343452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111019
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