A C-terminal Membrane Anchor Affects the Interactions of Prion Proteins with Lipid Membranes

Membrane attachment via a C-terminal glycosylphosphatidylinositol anchor is critical for conversion of PrP(C) into pathogenic PrP(Sc). Therefore the effects of the anchor on PrP structure and function need to be deciphered. Three PrP variants, including full-length PrP (residues 23–231, FL_PrP), N-t...

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Detalhes bibliográficos
Main Authors: Chu, Nam K., Shabbir, Waheed, Bove-Fenderson, Erin, Araman, Can, Lemmens-Gruber, Rosa, Harris, David A., Becker, Christian F. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208020/
https://ncbi.nlm.nih.gov/pubmed/25217642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587345
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