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Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine
BACKGROUND: The novel antidepressant agomelatine, a melatonergic MT(1)/MT(2) agonist combined with 5-HT(2c) serotonin antagonist properties, showed antidepressant action in preclinical and clinical studies. There is a general agreement that the therapeutic action of antidepressants needs the activat...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207903/ https://ncbi.nlm.nih.gov/pubmed/25332063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-014-0119-1 |
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