Missense Mutation Lys18Asn in Dystrophin that Triggers X-Linked Dilated Cardiomyopathy Decreases Protein Stability, Increases Protein Unfolding, and Perturbs Protein Structure, but Does Not Affect Protein Function

Genetic mutations in a vital muscle protein dystrophin trigger X-linked dilated cardiomyopathy (XLDCM). However, disease mechanisms at the fundamental protein level are not understood. Such molecular knowledge is essential for developing therapies for XLDCM. Our main objective is to understand the e...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Singh, Surinder M., Bandi, Swati, Shah, Dinen D., Armstrong, Geoffrey, Mallela, Krishna M. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207752/
https://ncbi.nlm.nih.gov/pubmed/25340340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110439
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados