Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus

[Image: see text] Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort was initiated around a quinaz...

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Detalhes bibliográficos
Main Authors: Schroeder, Chad E., Yao, Tuanli, Sotsky, Julie, Smith, Robert A., Roy, Sudeshna, Chu, Yong-Kyu, Guo, Haixun, Tower, Nichole A., Noah, James W., McKellip, Sara, Sosa, Melinda, Rasmussen, Lynn, Smith, Layton H., White, E. Lucile, Aubé, Jeffrey, Jonsson, Colleen B., Chung, Donghoon, Golden, Jennifer E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207539/
https://ncbi.nlm.nih.gov/pubmed/25244572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501203v
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