In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

Dysfunctional endothelium contributes to more disease than any other tissue in the body. Small interfering RNAs (siRNAs) have the potential to help study and treat endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challengi...

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Autores principales: Dahlman, James E., Barnes, Carmen, Khan, Omar, Thiriot, Aude, Jhunjunwala, Siddharth, Shaw, Taylor E., Xing, Yiping, Sager, Hendrik B., Sahay, Gaurav, Speciner, Lauren, Bader, Andrew, Bogorad, Roman L., Yin, Hao, Racie, Tim, Dong, Yizhou, Jiang, Shan, Seedorf, Danielle, Dave, Apeksha, Sandu, Kamaljeet S., Webber, Matthew J., Novobrantseva, Tatiana, Ruda, Vera M., Lytton-Jean, Abigail K.R., Levins, Christopher G., Kalish, Brian, Mudge, Dayna K., Perez, Mario, Abezgauz, Ludmila, Dutta, Partha, Smith, Lynelle, Charisse, Klaus, Kieran, Mark W., Fitzgerald, Kevin, Nahrendorf, Matthias, Danino, Dganit, Tuder, Rubin M., von Andrian, Ulrich H., Akinc, Akin, Schroeder, Avi, Panigrahy, Dipak, Kotelianski, Victor, Langer, Robert, Anderson, Daniel G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207430/
https://ncbi.nlm.nih.gov/pubmed/24813696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2014.84
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