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Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally considered causal for synaptic loss and neurodegeneration in AD. We elaborate on and update arguments for and against t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207354/ https://ncbi.nlm.nih.gov/pubmed/25231068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0135-5 |
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