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Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally considered causal for synaptic loss and neurodegeneration in AD. We elaborate on and update arguments for and against t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207354/ https://ncbi.nlm.nih.gov/pubmed/25231068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0135-5 |
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