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Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 am versus 4 pm

The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylpre...

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Détails bibliographiques
Auteurs principaux: Fisher, Lynn E., Ludwig, Elizabeth A., Wald, Jeffrey A., Sloan, Rita R., Middleton, Elliott, Jusko, William J.
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207308/
https://ncbi.nlm.nih.gov/pubmed/1535301
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