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Targeted molecular therapies against epidermal growth factor receptor: Past experiences and challenges
Epidermal growth factor receptor (EGFR) has emerged as a highly attractive therapeutic target in glioblastoma (GBM) based on its high frequency of gene amplification and mutation and its identification as an upstream trigger of dysregulated cell signaling cascades that drive GBM pathophysiology. Ext...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207137/ https://ncbi.nlm.nih.gov/pubmed/25342602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou232 |
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