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Targeted molecular therapies against epidermal growth factor receptor: Past experiences and challenges

Epidermal growth factor receptor (EGFR) has emerged as a highly attractive therapeutic target in glioblastoma (GBM) based on its high frequency of gene amplification and mutation and its identification as an upstream trigger of dysregulated cell signaling cascades that drive GBM pathophysiology. Ext...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Reardon, David A., Wen, Patrick Y., Mellinghoff, Ingo K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207137/
https://ncbi.nlm.nih.gov/pubmed/25342602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou232
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