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Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment strategies
Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findings in glioblastomas. EGFR is at the top of a downstream signaling cascade that regulates important characteristics of glioblastoma cells, including cellular proliferation, migration, and survival. Ta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207136/ https://ncbi.nlm.nih.gov/pubmed/25342600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou222 |
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