Disease-Targeted Sequencing of Ion Channel Genes identifies de novo mutations in Patients with Non-Familial Brugada Syndrome

Brugada syndrome (BrS) is one of the ion channelopathies associated with sudden cardiac death (SCD). The most common BrS-associated gene (SCN5A) only accounts for approximately 20–25% of BrS patients. This study aims to identify novel mutations across human ion channels in non-familial BrS patients...

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Hauptverfasser: Juang, Jyh-Ming Jimmy, Lu, Tzu-Pin, Lai, Liang-Chuan, Ho, Chia-Chuan, Liu, Yen-Bin, Tsai, Chia-Ti, Lin, Lian-Yu, Yu, Chih-Chieh, Chen, Wen-Jone, Chiang, Fu-Tien, Yeh, Shih-Fan Sherri, Lai, Ling-Ping, Chuang, Eric Y., Lin, Jiunn-Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206841/
https://ncbi.nlm.nih.gov/pubmed/25339316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06733
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