Utilizing Multiple in Silico Analyses to Identify Putative Causal SCN5A Variants in Brugada Syndrome

Brugada syndrome (BrS) is an inheritable sudden cardiac death disease mainly caused by SCN5A mutations. Traditional approaches can be costly and time-consuming if all candidate variants need to be validated through in vitro studies. Therefore, we developed a new approach by combining multiple in sil...

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Главные авторы: Juang, Jyh-Ming Jimmy, Lu, Tzu-Pin, Lai, Liang-Chuan, Hsueh, Chia-Hsiang, Liu, Yen-Bin, Tsai, Chia-Ti, Lin, Lian-Yu, Yu, Chih-Chieh, Hwang, Juey-Jen, Chiang, Fu-Tien, Yeh, Sherri Shih-Fan, Chen, Wen-Pin, Chuang, Eric Y., Lai, Ling-Ping, Lin, Jiunn-Lee
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902491/
https://ncbi.nlm.nih.gov/pubmed/24463578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03850
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