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Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains

Specific sugar residues and their linkages form the basis of molecular recognition for interactions of glycoproteins with other biomolecules. Seemingly small changes, like the addition of a single monosaccharide in the covalently attached glycan component of glycoproteins, can greatly affect these i...

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Bibliografiske detaljer
Main Authors: Faller, Christina E., Guvench, Olgun
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206607/
https://ncbi.nlm.nih.gov/pubmed/25116630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24668
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