CD44 Receptor Unfolding Enhances Binding by Freeing Basic Amino Acids to Contact Carbohydrate Ligand

The extracellular carbohydrate-binding domain of the Type I transmembrane receptor CD44 is known to undergo affinity switching, where change in conformation leads to enhanced binding of its carbohydrate ligand hyaluronan. Separate x-ray crystallographic and NMR experiments have led to competing expl...

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Autores principales: Favreau, Amanda J., Faller, Christina E., Guvench, Olgun
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2013
Materias:
Proteins and Nucleic Acids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762344/
https://ncbi.nlm.nih.gov/pubmed/24010665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.041
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