PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation

AMP-activated protein kinase α1 knockout (prkaa1(−/−)) mice manifest splenomegaly and anemia. The underlying molecular mechanisms, however, remain to be established. In this study, we tested the hypothesis that defective autophagy-dependent mitochondrial clearance in prkaa1(−/−) mice exacerbates oxi...

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Autori principali: Zhu, Huaiping, Foretz, Marc, Xie, Zhonglin, Zhang, Miao, Zhu, Zhiren, Xing, Junjie, Leclerc, Jocelyne, Gaudry, Murielle, Viollet, Benoit, Zou, Ming-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Basic Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206532/
https://ncbi.nlm.nih.gov/pubmed/24988326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29197
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