HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques

To target immune responses towards invariable regions of the virus, we engineered DNA-based immunogens encoding conserved elements (CE) of HIV-1 p24(gag). This conserved element vaccine is designed to avoid decoy epitopes by focusing responses to critical viral elements. We previously reported that...

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Autori principali: Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Rolland, Morgane, Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206485/
https://ncbi.nlm.nih.gov/pubmed/25338098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111085
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