Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study

INTRODUCTION: The potential for ezogabine/retigabine (EZG/RTG) and its N-acetyl metabolite (NAMR) to inhibit the transporter protein P-glycoprotein-(P-gp)-mediated digoxin transport was tested in vitro. EZG/RTG did not inhibit P-gp. However, NAMR inhibited P-gp in a concentration-dependent manner. B...

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Hlavní autoři: Tompson, Debra J, Crean, Christopher S, Buraglio, Mauro, Arumugham, Thangam
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206209/
https://ncbi.nlm.nih.gov/pubmed/25342921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S64131
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