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Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members
Signaling by receptor activator of nuclear factor-κB (RANK) in response to its ligand RANKL, which is a member of the tumor necrosis factor (TNF) superfamily of cytokines, stimulates osteoclast formation and bone resorption. Thus, this ligand-receptor pair is a therapeutic target for various disorde...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4206197/ https://ncbi.nlm.nih.gov/pubmed/25140055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004948 |
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