VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-1R Define a Novel Mechanism of Aggressive Prostate Cancer

We demonstrate that the VEGF receptor, neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses IGF-1R expression and signaling and the mechanism inv...

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Detalhes bibliográficos
Main Authors: Goel, Hira Lal, Chang, Cheng, Pursell, Bryan, Leav, Irwin, Lyle, Stephen, Xi, Hualin Simon, Hsieh, Chung-Cheng, Adisetiyo, Helty, Roy-Burman, Pradip, Coleman, Ilsa M., Nelson, Peter S., Vessella, Robert L., Davis, Roger J., Plymate, Stephen R., Mercurio, Arthur M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205964/
https://ncbi.nlm.nih.gov/pubmed/22777769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0085
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