Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated that a crucial insulin epitope (B:9-23) is presented to diabetogenic CD4 T cells by IA(g7) in a weakly bound register. The importance of antigenic peptides with low-affinity HLA binding in human autoimmune disease...

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Autors principals: Yang, Junbao, Chow, I-Ting, Sosinowski, Tomasz, Torres-Chinn, Nadia, Greenbaum, Carla J., James, Eddie A., Kappler, John W., Davidson, Howard W., Kwok, William W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205657/
https://ncbi.nlm.nih.gov/pubmed/25267644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416864111
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