Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiq...

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Detalhes bibliográficos
Main Authors: Keller, Johannes, Catala-Lehnen, Philip, Huebner, Antje K., Jeschke, Anke, Heckt, Timo, Lueth, Anja, Krause, Matthias, Koehne, Till, Albers, Joachim, Schulze, Jochen, Schilling, Sarah, Haberland, Michael, Denninger, Hannah, Neven, Mona, Hermans-Borgmeyer, Irm, Streichert, Thomas, Breer, Stefan, Barvencik, Florian, Levkau, Bodo, Rathkolb, Birgit, Wolf, Eckhard, Calzada-Wack, Julia, Neff, Frauke, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabĕ, Klutmann, Susanne, Tsourdi, Elena, Hofbauer, Lorenz C., Kleuser, Burkhard, Chun, Jerold, Schinke, Thorsten, Amling, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205484/
https://ncbi.nlm.nih.gov/pubmed/25333900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6215
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