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Specific increase in potency via structure-based design of a T cell receptor

Adoptive immunotherapy with antigen-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor antigens are non-reactive “self” proteins, which presents an immunotherapy design challenge. Recent studies have shown that tumor-specific T cell receptors (TCRs) can be transd...

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Detalhes bibliográficos
Main Authors: Malecek, Karolina, Grigoryan, Arsen, Zhong, Shi, Gu, Wei Jun, Johnson, Laura A., Rosenberg, Steven A., Cardozo, Timothy, Krogsgaard, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205480/
https://ncbi.nlm.nih.gov/pubmed/25070852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302344
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