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Protein Phosphatase 1 (PP1) and Casein kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia
BACKGROUND: Ikaros is a DNA-binding protein that acts as master-regulator of hematopoiesis and a tumor suppressor. In thymocytes and T-cell leukemia, Ikaros negatively regulates transcription of terminal deoxynucleotide transferase (TdT), a key protein in lymphocyte differentiation. The signaling pa...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4205270/ https://ncbi.nlm.nih.gov/pubmed/25214003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25221 |
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