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Continuous requirement for the T cell receptor for regulatory T cell function

Foxp3(+) regulatory T cells (T(reg) cells) maintain immunological tolerance and their deficiency results in fatal multi-organ autoimmunity. Although heightened T cell receptor (TCR) signaling is critical for the differentiation of T(reg) cells, the role of TCR signaling in T(reg) cell function remai...

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Detalhes bibliográficos
Main Authors: Levine, Andrew G, Arvey, Aaron, Jin, Wei, Rudensky, Alexander Y
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205268/
https://ncbi.nlm.nih.gov/pubmed/25263123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3004
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