A Distinct Subfraction of Aβ is Responsible for the High-Affinity Pittsburgh Compound B (PIB) Binding Site in Alzheimer’s Disease Brain

The positron emitting (PET) (11)C-labeled Pittsburgh Compound B (PIB) ligand is used to image β-amyloid (Aβ) deposits in the brains of living subjects with the intent of detecting early stages of Alzheimer’s disease (AD). However, deposits of human-sequence Aβ in APP transgenic mice and nonhuman pri...

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Main Authors: Matveev, Sergey V., Spielmann, H. Peter, Metts, Brittney M., Chen, Jing, Onono, Fredrick, Zhu, Haining, Scheff, Stephen W., Walker, Lary C., LeVine, Harry
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205261/
https://ncbi.nlm.nih.gov/pubmed/24995708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12815
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