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Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase

The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site. We report a crystal structure of carbon monoxide (CO) inhibited nitrogenase MoFe-protein at 1.50 Å resolution, revealing a CO molecule bridging Fe2 and Fe6...

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Main Authors: Spatzal, Thomas, Perez, Kathryn A., Einsle, Oliver, Howard, James B., Rees, Douglas C.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205161/
https://ncbi.nlm.nih.gov/pubmed/25258081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1256679
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