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Poliovirus proves IRES-istible in vivo
The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5′ noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at...
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2004
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC420512/ https://ncbi.nlm.nih.gov/pubmed/15199401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422139 |
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