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Poliovirus proves IRES-istible in vivo

The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5′ noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at...

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Библиографические подробности
Главный автор: Semler, Bert L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC420512/
https://ncbi.nlm.nih.gov/pubmed/15199401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422139
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