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Poliovirus proves IRES-istible in vivo

The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5′ noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Autor principal: Semler, Bert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC420512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15199401/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22139
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