Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

Uracil-DNA glycosylase (UNG) is involved in base excision repair of aberrant uracil residues in nuclear and mitochondrial DNA. Ung knockout mice generated by gene targeting are viable, fertile, and phenotypically normal and have regular mutation rates. However, when exposed to a nitric oxide donor,...

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Bibliografiske detaljer
Main Authors: Endres, Matthias, Biniszkiewicz, Detlev, Sobol, Robert W., Harms, Christoph, Ahmadi, Michael, Lipski, Andreas, Katchanov, Juri, Mergenthaler, Philipp, Dirnagl, Ulrich, Wilson, Samuel H., Meisel, Andreas, Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420508/
https://ncbi.nlm.nih.gov/pubmed/15199406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420926
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