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Sorting out the trash: the spatial nature of eukaryotic protein quality control
Failure to maintain protein homeostasis is associated with aggregation and cell death, and underies a growing list of pathologies including neurodegenerative diseases, aging and cancer. Misfolded proteins can be toxic and interfere with normal cellular functions, particularly during proteotoxic stre...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4204729/ https://ncbi.nlm.nih.gov/pubmed/24463332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2013.12.006 |
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