A phase I study of pemetrexed in patients with relapsed or refractory acute leukemia

PURPOSE: To investigate the toxicity profile, activity, pharmacokinetics, and pharmacodynamics of pemetrexed in leukemia. PATIENTS AND METHODS: Patients with refractory or relapsed acute leukemia were eligible. A phase I 3+3 design was implemented. Pemetrexed was infused intravenously (IV) over 25 m...

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Detalhes bibliográficos
Main Authors: Abdel-Karim, Isam, Plunkett, William K., O’Brien, Susan, Giles, Francis, Thomas, Deborah, Faderl, Stefan, Ravandi, Farhad, Rios, Mary Beth, Du, Min, Schneck, Karen B., Chen, Victor J., Lin, Boris K., Nicol, Steven J., Kantarjian, Hagop M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204658/
https://ncbi.nlm.nih.gov/pubmed/20091088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-009-9369-7
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