Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3.

A systematic evaluation of structure-activity information led to the construction of genetically engineered interleukin 3 (IL-3) receptor agonists (synthokines) with enhanced hematopoietic potency. SC-55494, the most extensively characterized member of this series, exhibits 10- to 20-fold greater bi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Thomas, J W, Baum, C M, Hood, W F, Klein, B, Monahan, J B, Paik, K, Staten, N, Abrams, M, McKearn, J P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42045/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7537376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3779
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