The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.

The receptor tyrosine kinases (RTKs) c-kit and platelet-derived growth factor receptor alpha chain (PDG-FRa) are encoded at the white spotting (W) and patch (Ph) loci on mouse chromosome 5. While W mutations affect melanogenesis, gametogenesis, and hematopoiesis, the Ph mutation affects melanogenesi...

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Detalhes bibliográficos
Main Authors: Duttlinger, R, Manova, K, Berrozpe, G, Chu, T Y, DeLeon, V, Timokhina, I, Chaganti, R S, Zelenetz, A D, Bachvarova, R F, Besmer, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42040/
https://ncbi.nlm.nih.gov/pubmed/7537375
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