CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

Dectin-1 functions as a pattern recognition receptor for sensing fungal infection. It has been well-established that Dectin-1 induces innate immune responses through caspase recruitment domain-containing protein 9 (CARD9)–mediated NF-κB activation. In this study, we find that CARD9 is dispensable fo...

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Autori principali: Jia, Xin-Ming, Tang, Bing, Zhu, Le-Le, Liu, Yan-Hui, Zhao, Xue-Qiang, Gorjestani, Sara, Hsu, Yen-Michael S., Yang, Long, Guan, Jian-Hong, Xu, Guo-Tong, Lin, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203953/
https://ncbi.nlm.nih.gov/pubmed/25267792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132349
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