Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

The mutational repertoire of cancers creates the neoepitopes that make cancers immunogenic. Here, we introduce two novel tools that identify, with relatively high accuracy, the small proportion of neoepitopes (among the hundreds of potential neoepitopes) that protect the host through an antitumor T...

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Bibliographische Detailangaben
Hauptverfasser: Duan, Fei, Duitama, Jorge, Al Seesi, Sahar, Ayres, Cory M., Corcelli, Steven A., Pawashe, Arpita P., Blanchard, Tatiana, McMahon, David, Sidney, John, Sette, Alessandro, Baker, Brian M., Mandoiu, Ion I., Srivastava, Pramod K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203949/
https://ncbi.nlm.nih.gov/pubmed/25245761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141308
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