microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity

BACKGROUND: The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer. METHODS AND RESULTS: Here we use deep sequencing analysis of previously published...

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Detalhes bibliográficos
Main Authors: Martin, Elizabeth C, Rhodes, Lyndsay V, Elliott, Steven, Krebs, Adrienne E, Nephew, Kenneth P, Flemington, Erik K, Collins-Burow, Bridgette M, Burow, Matthew E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203920/
https://ncbi.nlm.nih.gov/pubmed/25283550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-229
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