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A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data
Intra-tumor heterogeneity reflects cancer genome evolution and provides key information for diagnosis and treatment. When bulk tumor tissues are profiled for somatic copy number alterations (sCNA) and point mutations, it may be difficult to estimate their cellular fractions when a mutation falls wit...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4203890/ https://ncbi.nlm.nih.gov/pubmed/25253082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0473-4 |
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