A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ...

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Bibliografische gegevens
Hoofdauteurs: Rosenfeld, Myrna R, Ye, Xiaobu, Supko, Jeffrey G, Desideri, Serena, Grossman, Stuart A, Brem, Steven, Mikkelson, Tom, Wang, Daniel, Chang, Yunyoung C, Hu, Janice, McAfee, Quentin, Fisher, Joy, Troxel, Andrea B, Piao, Shengfu, Heitjan, Daniel F, Tan, Kay-See, Pontiggia, Laura, O’Dwyer, Peter J, Davis, Lisa E, Amaravadi, Ravi K
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2014
Onderwerpen:
Clinical Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203513/
https://ncbi.nlm.nih.gov/pubmed/24991840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28984
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