A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ...

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Dettagli Bibliografici
Autori principali: Rosenfeld, Myrna R, Ye, Xiaobu, Supko, Jeffrey G, Desideri, Serena, Grossman, Stuart A, Brem, Steven, Mikkelson, Tom, Wang, Daniel, Chang, Yunyoung C, Hu, Janice, McAfee, Quentin, Fisher, Joy, Troxel, Andrea B, Piao, Shengfu, Heitjan, Daniel F, Tan, Kay-See, Pontiggia, Laura, O’Dwyer, Peter J, Davis, Lisa E, Amaravadi, Ravi K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Clinical Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203513/
https://ncbi.nlm.nih.gov/pubmed/24991840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28984
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