The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease

A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell cycle protein. We performed genetic fine mapping analysis of the...

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Autores principales: Fu, Yi-Ping, Kohaar, Indu, Moore, Lee E., Lenz, Petra, Figueroa, Jonine D., Tang, Wei, Porter-Gill, Patricia, Chatterjee, Nilanjan, Scott-Johnson, Alexandra, Garcia-Closas, Montserrat, Muchmore, Brian, Baris, Dalsu, Paquin, Ashley, Ylaya, Kris, Schwenn, Molly, Apolo, Andrea B., Karagas, Margaret R., Tarway, McAnthony, Johnson, Alison, Mumy, Adam, Schned, Alan, Guedez, Liliana, Jones, Michael A., Kida, Masatoshi, Monawar Hosain, GM, Malats, Nuria, Kogevinas, Manolis, Tardon, Adonina, Serra, Consol, Carrato, Alfredo, Garcia-Closas, Reina, Lloreta, Josep, Wu, Xifeng, Purdue, Mark, Andriole, Gerald L., Grubb, Robert L., Black, Amanda, Landi, Maria T., Caporaso, Neil E., Vineis, Paolo, Siddiq, Afshan, Bueno-de-Mesquita, H. Bas, Trichopoulos, Dimitrios, Ljungberg, Börje, Severi, Gianluca, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth C., Tjønneland, Anne, Brennan, Paul, Chang-Claude, Jenny, Riboli, Elio, Prescott, Jennifer, Chen, Constance, De Vivo, Immaculata, Govannucci, Edward, Hunter, David, Kraft, Peter, Lindstrom, Sara, Gapstur, Susan M., Jacobs, Eric J., Diver, W. Ryan, Albanes, Demetrius, Weinstein, Stephanie J., Virtamo, Jarmo, Kooperberg, Charles, Hohensee, Chancellor, Rodabough, Rebecca J., Cortessis, Victoria K., Conti, David V., Gago-Dominguez, Manuela, Stern, Mariana C., Pike, Malcolm C., Van Den Berg, David, Yuan, Jian-Min, Haiman, Christopher A., Cussenot, Olivier, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Porru, Stefano, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Grossman, H. Barton, Wang, Zhaoming, Deng, Xiang, Chung, Charles C., Hutchinson, Amy, Burdette, Laurie, Wheeler, William, Fraumeni, Joseph, Chanock, Stephen J., Hewitt, Stephen M., Silverman, Debra T., Rothman, Nathaniel, Prokunina-Olsson, Ludmila
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203382/
https://ncbi.nlm.nih.gov/pubmed/25320178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1531
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