Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk

Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs within 100 Kb of rs2294008 in addition to 33 markers genotyped in one of the reported genom...

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Hlavní autoři: Fu, Yi-Ping, Kohaar, Indu, Rothman, Nathaniel, Earl, Julie, Figueroa, Jonine D., Ye, Yuanqing, Malats, Núria, Tang, Wei, Liu, Luyang, Garcia-Closas, Montserrat, Muchmore, Brian, Chatterjee, Nilanjan, Tarway, McAnthony, Kogevinas, Manolis, Porter-Gill, Patricia, Baris, Dalsu, Mumy, Adam, Albanes, Demetrius, Purdue, Mark P., Hutchinson, Amy, Carrato, Alfredo, Tardón, Adonina, Serra, Consol, García-Closas, Reina, Lloreta, Josep, Johnson, Alison, Schwenn, Molly, Karagas, Margaret R., Schned, Alan, Diver, W. Ryan, Gapstur, Susan M., Thun, Michael J., Virtamo, Jarmo, Chanock, Stephen J., Fraumeni, Joseph F., Silverman, Debra T., Wu, Xifeng, Real, Francisco X., Prokunina-Olsson, Ludmila
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324016/
https://ncbi.nlm.nih.gov/pubmed/22416122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202189109
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