Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer

A recent genome-wide association study of bladder cancer identified the UGT1A gene cluster on chromosome 2q37.1 as a novel susceptibility locus. The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal of aromatic amines. Bioacti...

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Detalhes bibliográficos
Main Authors: Tang, Wei, Fu, Yi-Ping, Figueroa, Jonine D., Malats, Núria, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Kogevinas, Manolis, Baris, Dalsu, Thun, Michael, Hall, Jennifer L., De Vivo, Immaculata, Albanes, Demetrius, Porter-Gill, Patricia, Purdue, Mark P., Burdett, Laurie, Liu, Luyang, Hutchinson, Amy, Myers, Timothy, Tardón, Adonina, Serra, Consol, Carrato, Alfredo, Garcia-Closas, Reina, Lloreta, Josep, Johnson, Alison, Schwenn, Molly, Karagas, Margaret R., Schned, Alan, Black, Amanda, Jacobs, Eric J., Diver, W. Ryan, Gapstur, Susan M., Virtamo, Jarmo, Hunter, David J., Fraumeni, Joseph F., Chanock, Stephen J., Silverman, Debra T., Rothman, Nathaniel, Prokunina-Olsson, Ludmila
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313801/
https://ncbi.nlm.nih.gov/pubmed/22228101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr619
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