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Applying E(max) model and bivariate thin plate splines to assess drug interactions
We review the semiparametric approach previously proposed by Kong and Lee and extend it to a case in which the dose-effect curves follow the E(max) model instead of the median effect equation. When the maximum effects for the investigated drugs are different, we provide a procedure to obtain the add...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4203317/ https://ncbi.nlm.nih.gov/pubmed/20036878 |
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