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E(max) model and interaction index for assessing drug interaction in combination studies
Applying the E(max) model in a Lowe additivity model context, we analyze data from a combination study of trimetrexate (TMQ) and AG2034 (AG) in media of low and high concentrations of folic acid (FA). The E(max) model provides a sufficient fit to the data. TMQ is more potent than AG in both low and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974574/ https://ncbi.nlm.nih.gov/pubmed/20036904 |
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