Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity.

Ítems similars

• An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.
  per: Vogan, K J, et al.
  Publicat: (1996)
• Helix 2 of the paired domain plays a key role in the regulation of DNA-binding by the Pax-3 homeodomain.
  per: Fortin, A S, et al.
  Publicat: (1998)
• A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.
  per: Epstein, D J, et al.
  Publicat: (1993)
• A new missense mutation in the paired domain of the mouse Pax3 gene
  per: Ohno, Tamio, et al.
  Publicat: (2017)
• Molecular basis of splotch and Waardenburg Pax-3 mutations.
  per: Chalepakis, G, et al.
  Publicat: (1994)